Low-affinity Nerve Growth Factor Receptor (ngfr) Is a Marker of Basal Urothelial Cells – Implications for Urothelial Regeneration and Renewal

The bladder is lined by urothelium a mitoticallyquiescent epithelium in situ characterised by an extremely low turnover rate and long-lived cells. However, in response to injury, infection or other stimuli, the urothelium develops a highly regenerative response. As a self-renewing tissue, there is assumed to be a resident progenitor population. However, no specific population has yet been identified that acts as a stem cell in human urothelium.